The goal of the EPIGEN project is to understand how epigenetic mechanisms regulate bio
logical processes, determine phenotypic variation and contribute to the onset and progression of diseases.
The EPIGEN project is highly multidisciplinary and involves 70 Italian research teams working in close collaboration. Our laboratories employ different experimental models, approaches and technologies so we aim to establish a multidisciplinary national network and keep these synergies beyond the lifetime of the project.
EPIGEN is organized in 8 subprojects, five of which constitute the project's research axes and three are platforms for NGS sequencing, bioinformatics and cellular imaging as outlined here below.
Next Generation Sequencing Service and Development Platform
Coordinator: Michele Morgante. Institute of Applied Genomics (IGA), Udine.
Bioinformatics platform for integration of epigenomics data and systems biology.
Coordinator: Graziano Pesole. Institute of Biomembrane and Bioenergetics (IBBE) CNR, Bari.
Cellular imaging Platform: Deciphering the epigenome with nuclear imaging techniques
Coordinator: Alberto Luini. Institute of Protein Biochemistry (IBP) CNR, Naples.
Role of chromatin structure, DNA methylation and nuclear architecture in epigenetic regulation.
Coordinator: Marco Bianchi. San Raffaele University, Milan.
Epigenetic control through the non-coding component of the genome: structure and dynamics.
Coordinator: Valerio Orlando. Fondazione Santa Lucia, Rome.
Epigenetic control of cellular identity and human pathologies
Coordinator: Stefano Piccolo. University of Padua.
Epigenetic drugs for therapeutic use
Coordinator: Saverio Minucci. European Institute of Oncology, Milan.
Epigenomic studies in plants of agricultural interest
Coordinator: Serena Varotto. University of Padua.
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